The series focuses on a Japanese garage band called Plastic Chew and their struggles to make it big while remaining true to their musical sensibilities and juggling school and part-time jobs. Internal conflict arises because not all four band members have the same talent levels and plans for the future; Saiyuri and Jun are romantically involved, but Jun is prone to psychological reliance on the man who raised him, someone the other band members don't trust.
The members of Plastic Chew are the orphaned Jun Imai, who sings and plays the guitar along with the only female band member, Sayuri Tsushima; the bass guitarist Atsushi Kato; and Keigo Miyake, the drummer.
The series is also published in Finland by Pauna Media Group.
English-language critics were lukewarm towards Yonen Buzz. IGN's Richard George stated: "Yonen Buzz is what happens when you take interesting characters and do absolutely nothing with them." He described the "interesting and fleshed out" characters as the series' "greatest assets" and enjoyed the page layouts, but criticized the "repetitive character design" and that it "lacks a resolution to any plot". Rhia Docherty of Mangalife liked the concept of the series, but disliked the confusion in the panels and style changes, and that the concept failed to work and became confusing.
Critical reaction towards the prequel was relatively positive. Leroy Douresseaux of Coolstreak Cartoons wrote that the combination of "her composition and graphic design" inspired by shojo manga, manga targeted towards teen girls, and "the flavorings of shonen manga", manga targeted towards teen boys, "adds an essence to Yonen Buzz: Plastic Chew that makes for a fun read." While noting "plot contrivances" and that Jun is an "archetypal sensitive dreamboat", PopCultureShock's Phil Guie stated: "Yonen Buzz is, above all, about the idea that music, like a lot of artistic endeavors, is capable of bringing people together, and how joyous it can be meeting others with the same passion as your own." Writing for Mania Entertainment, Erin Jones commented on the "bland" character designs, "amateurish" art, and that some aspects of the plot were "ridiculously contrived". Jones concluded that while it might appeal to fans of the series, "Yonen Buzz: Plastic Chew is one of those titles that I’d just rather sweep under the carpet and forget about--particularly the first few chapters."