Born in Worthington, Ohio, Plotnick is based in Hollywood. Plotnick is an openly gay actor, best known for performances on Ellen, Buffy the Vampire Slayer, as the voice of Xandir on Drawn Together, and his drag persona, "Evie Harris" in Girls Will Be Girls.
Along with co-stars Miss Coco Peru and Varla Jean Merman, Plotnick shared the Best Actor Grand Jury Award at Outfest 2003 and "Best Actress" honors at the 2003 U.S. Comedy Arts Festival for his role in Girls Will Be Girls.
Plotnick has also appeared in television commercials as well; the most recent (as of January 2010) being for Trix cereal, where he posed as a French waiter.