Indigo Vertigo is described as "the hallucinatory spectacle of one woman’s experience at the brink of reality." A quote from Warren Ellis on the back cover reads, "Like Sylvia Plath fucking David Lynch".
According to Schaffer, who acknowledges a heavy influence from Lynch (and also Japanese auteur, Shinya Tsukamoto), the book is an experiment in subjective storytelling, and came about as the result of an unconventional, intuitive creative process developed by himself and KatieJane Garside (vocalist with extreme rock band Queenadreena).
In an interview posted on comics news site The Pulse in 2005, Schaffer explains - "Indigo Vertigo is an attempt to connect to the reader by acknowledging the demons and empty spaces that are within everybody. If you’re going to do something like that without pretension or agenda, you have to first expose the same thing from within yourself, and so this book is a glimpse of that truth, from the perspective of both Katie and myself, with a little bit of space for the reader. It’s a book designed to reach out through example, and it will come alive if you bring something of yourself to it."