Harutaro Hanazono, a cheerful and outspoken boy, enrolls at his new high school a month late, as he has been recovering from a bone marrow transplant to treat his leukemia. He is befriended by Shota Mikuni, who is also friends with Kai Majima, an otaku. Harutaro finds Kai annoying. The story follows the school life of Harutaro.
Comics Worth Reading's Johanna Draper Carlson criticises the first volume of the manga for its plot which "jumps around a good deal". A later review by Johanna Draper Carlson comments on the diversity of personalities in the second volume of the manga. Johanna Draper Carlson at Comics Worth Reading comments on Fumi Yoshinaga's treatment of the manga like an anthology from her previous work, Antique Bakery.About.com's Deb Aoki commends the manga for its "charming mix of slice of life comedy and high school romance" but criticises it for the author's assumption that the "reader knows and understands manga culture and otaku slang". She also criticises the manga for having too much dialogue. Erin Finnegan at Pop Shock Culture comments on her uncertainty of the demographic of the manga. Mania.com's Patricia Beard comments on the manga's realistic "small glimpses of school life".Jason Thompson, writing for the appendix to Manga: The Complete Guide, describes Flower of Life as being Yoshinaga's "take on the high school comedy genre". While there is use of the "same basic elements" in terms of the plot, Thompson regards the characters as being "entirely original" and as being able to "carry the story".